October 30, 2020


Hypothesis: Betaine decreases the pathogenicity of Covid-19.

Betaine in Inflammation: Mechanistic Aspects and Applications

Guangfu Zhao,1 Fang He,1 Chenlu Wu,1 Pan Li,1 Nengzhang Li,1 Jinping Deng,2 Guoqiang Zhu,3 Wenkai Ren,2,3,* and Yuanyi Peng1,*


Betaine is known as trimethylglycine and is widely distributed in animals, plants, and microorganisms. Betaine is known to function physiologically as an important osmoprotectant and methyl group donor. Accumulating evidence has shown that betaine has anti-inflammatory functions in numerous diseases. Mechanistically, betaine ameliorates sulfur amino acid metabolism against oxidative stress, inhibits nuclear factor-κB activity and NLRP3 inflammasome activation, regulates energy metabolism, and mitigates endoplasmic reticulum stress and apoptosis. Consequently, betaine has beneficial actions in several human diseases, such as obesity, diabetes, cancer, and Alzheimer’s disease.Keywords: betaine, oxidative stress, endoplasmic reticulum, inflammation, obesity